Study of acute toxicity and cumulative activity of polyphenolic powders derived from pomegranate peel and grape seed waste

This article presents studies to determine the acute toxicity and cumulative activity of polyphenolic powders derived from pomegranate peel grape seed. When administered intragastrically mice in doses 500 2000 mg/kg, no was detected, animal death observed, deviations norm other external parameters were observed. The study preparations (PPPP) seed (PPGS) showed that they belong V class chemical compounds (practically non-toxic) according OEC classification, LD50 on -˃2000 mg/kg. group with average weak properties. These high biological obtained food waste Turkestan region, such as seeds. In recent years, there has been an active search for plant sources bioactive compounds, among widely consumed fruits, which are considered excellent source polyphenols, relation use industrial waste, leaders. appropriateness their human consumption confirmed by low level risks terms absence pronounced actions these preparations.